Caravaggio trained as a painter in Milan under a master who had himself trained under Titian. In his early twenties Caravaggio moved to Rome where, during the late 16th and early 17th centuries, many huge new churches and palazzi were being built and paintings were needed to fill them. During the Counter-Reformation the Roman Catholic Church searched for religious art with which to counter the threat of Protestantism, and for this task the artificial conventions of Mannerism, which had ruled art for almost a century, no longer seemed adequate. Caravaggio's novelty was a radicalnaturalism that combined close physical observation with a dramatic, even theatrical, use ofchiaroscuro. This came to be known as Tenebrism, the shift from light to dark with little intermediate value. He burst upon the Rome art scene in 1600 with the success of his first public commissions, the Martyrdom of Saint Matthew and Calling of Saint Matthew. Thereafter he never lacked commissions or patrons, yet he handled his success atrociously. He was jailed on several occasions, vandalized his own apartment, and ultimately had a death warrant issued for him by the Pope. An early published notice on him, dating from 1604 and describing his lifestyle three years previously, tells how "after a fortnight's work he will swagger about for a month or two with a sword at his side and a servant following him, from one ball-court to the next, ever ready to engage in a fight or an argument, so that it is most awkward to get along with him." In 1606 he killed a young man in a brawl and fled from Rome with a price on his head. He was involved in a brawl in Malta in 1608, and another in Naples in 1609, possibly a deliberate attempt on his life by unidentified enemies. This encounter left him severely injured. A year later, at the age of 38, he died of a fever in Porto Ercole, near Grosseto in Tuscany, while on his way to Rome to receive a pardon.

Infamous while he lived, Caravaggio was forgotten almost immediately after his death, and it was only in the 20th century that his importance to the development of Western art was rediscovered. Despite this, his influence on the new Baroque style that eventually emerged from the ruins ofMannerism was profound.

It can be seen directly or indirectly in the work of Rubens, Jusepe de Ribera, Bernini, and Rembrandt, and artists in the following generation heavily under his influence were called the "Caravaggisti" or "Caravagesques", as well as Tenebrists or "Tenebrosi" ("shadowists"). Andre Berne-Joffroy, Paul Valéry's secretary, said of him: "What begins in the work of Caravaggio is, quite simply, modern painting."